Synthesis of pyrazoles from sulfonyl hydrazone and benzyl acrylate under transition-metal-free conditions
Liqiang Hao, Zhichao Wang, Yangyang Wang, Zhaoziyuan Yang, Xian Liu, Xiaobo Xu, Yafei Ji
Abstract
Pyrazoles as an important class of heterocyclic compounds, are widely found in pharmaceuticals and bioactive natural products. Herein we report a [3 + 2] cycloaddition reaction for the synthesis of a series of pyrazoles, with the yield up to 77%. This approach exhibits many notable features, such as convenient operating conditions, excellent functional group compatibility and readily accessible raw materials, providing an alternative route for the construction of pyrazole derivatives.
Topics & Concepts
ChemistryHydrazoneSulfonylPyrazoleCycloadditionAcrylateSurface modificationTransition metalPolymer chemistryCombinatorial chemistryOrganic chemistryCatalysisMonomerPolymerPhysical chemistryAlkylSulfur-Based Synthesis TechniquesSynthesis and Catalytic ReactionsCyclopropane Reaction Mechanisms