Symptomatic Necrosis With Dual Immune-Checkpoint Inhibition and Radiosurgery for Brain Metastases
Eugene Vaios, R.F. Shenker, Peter G. Hendrickson, Zihan Wan, Donna Niedzwiecki, David Carpenter, Warren Floyd, Sebastian Winter, Helen A. Shih, Jörg Dietrich, Chunhao Wang, April K.S. Salama, Jeffrey Clarke, Karen Allen, Paul W. Sperduto, Trey C. Mullikin, John P. Kirkpatrick, Scott Floyd, Zachary J. Reitman
Abstract
This cohort study evaluates whether immune-checkpoint inhibition therapy concurrent with radiosurgery is associated with risk of symptomatic radionecrosis among US patients with brain metastases.
Topics & Concepts
RadiosurgeryMedicineImmune checkpointBrain metastasisImmune systemCohortOncologyInternal medicineImmunotherapyRadiation therapyCancerImmunologyMetastasisBrain Metastases and TreatmentLung Cancer Research StudiesRadiopharmaceutical Chemistry and Applications