Immunomodulation by systemic administration of human-induced pluripotent stem cell-derived mesenchymal stromal cells to enhance the therapeutic efficacy of cell-based therapy for treatment of myocardial infarction
Si-Jia Sun, Wing‐Hon Lai, Yu Jiang, Zhe Zhen, Rui Wei, Qizhou Lian, Song-Yan Liao, Hung‐Fat Tse
Abstract
Pre-transplantation systemic intravenous administration of hiPSC-MSCs induced immunomodulation and facilitated the survival of intramyocardially transplanted cells to improve cardiac function in MI.
Topics & Concepts
Mesenchymal stem cellMedicineTransplantationCell therapySystemic administrationStromal cellCancer researchInflammationStem cellImmunologyPathologyIn vivoInternal medicineBiologyCell biologyBiotechnologyMesenchymal stem cell researchTissue Engineering and Regenerative MedicineCardiac Fibrosis and Remodeling