Structure and mechanism behind the inhibitory effect of water soluble metalloporphyrins on Aβ<sub>1–42</sub>aggregation
Qianqian Zhang, Yiqing Liu, Jinming Wu, Lizhen Zeng, Jingjing Wei, Shitao Fu, Huixian Ye, Hailing Li, Zhonghong Gao
Abstract
If the tetraphenylporphyrin of a metalloporphyrin and an amyloid protein have opposite charge properties, the metalloporphyrin will be an effective inhibitor of this amyloid protein.
Topics & Concepts
Mechanism (biology)ChemistryInhibitory postsynaptic potentialWater solubleChemical physicsOrganic chemistryPhilosophyBiologyEpistemologyNeurosciencePorphyrin and Phthalocyanine ChemistryMetal-Catalyzed Oxygenation MechanismsPhotosynthetic Processes and Mechanisms