Antibiotic-induced microbiome depletion alters renal glucose metabolism and exacerbates renal injury after ischemia-reperfusion injury in mice
Yuika Osada, Shunsaku Nakagawa, Kanako Ishibe, Shota Takao, Aimi Shimazaki, Kotaro Itohara, Satoshi Imai, Atsushi Yonezawa, Takayuki Nakagawa, Kazuo Matsubara
Abstract
This study aimed to determine the impact of antibiotic-induced microbiome depletion (AIMD) on renal glucose metabolism in mice. This is the first report confirming that AIMD is associated with decreased levels of pyruvate, a key intermediate in glucose metabolism, which may have been caused by activation of renal gluconeogenesis. We hypothesized that AIMD can increase the susceptibility of the kidney to ischemia-reperfusion injury.
Topics & Concepts
GluconeogenesisIschemiaKidneyRenal injuryMicrobiomeCarbohydrate metabolismMetabolismMedicineReperfusion injuryUrinary systemAntibioticsAcute kidney injuryEndocrinologyInternal medicineBiologyBiochemistryBioinformaticsDialysis and Renal Disease ManagementChronic Kidney Disease and DiabetesRenal Transplantation Outcomes and Treatments