An endoperoxide-containing covalent organic framework as a singlet oxygen reservoir for cancer therapy
Fei Lü, Limeng Pan, Tong Wu, Wei Pan, Wen Gao, Na Li, Bo Tang
Abstract
An endoperoxide-containing COF was constructed to deliver extracellular singlet oxygen into cancer cells to realize light- and oxygen-independent oxidative damage for cancer therapy.
Topics & Concepts
Singlet oxygenCovalent bondCancer therapyChemistryOxygenCancer treatmentPhotochemistryCombinatorial chemistryCancerOrganic chemistryMedicineInternal medicineCovalent Organic Framework ApplicationsNanoplatforms for cancer theranosticsMetal-Organic Frameworks: Synthesis and Applications