Role of Endophytic Fungi in the Biosynthesis of Metal Nanoparticles and Their Potential as Nanomedicines
Hanadi Sawalha, Simon E. Moulton, Andreas Winkel, Meike Stiesch, Bita Zaferanloo
Abstract
Metal nanoparticles (MNPs) produced through biosynthesis approaches have shown favourable physical, chemical, and antimicrobial characteristics. The significance of biological agents in the synthesis of MNPs has been acknowledged as a promising alternative to conventional approaches such as physical and chemical methods, which are confronted with certain challenges. To meet these challenges, the use of endophytic fungi as nano-factories for the synthesis of MNPs has become increasingly popular worldwide in recent times. This review provides an overview of the synthesis of MNPs using endophytic fungi, the mechanisms involved, and their important biomedical applications. A special focus on different biomedical applications of MNPs mediated endophytic fungi involved their antibacterial, antifungal, antiviral, and anticancer applications and their potential as drug delivery agents. Furthermore, this review highlights the significance of the use of endophytic fungi for the green synthesis of MNPs and discusses the benefits, challenges, and prospects in this field.