Pharmacological Characterization of the Imipridone Anticancer Drug ONC201 Reveals a Negative Allosteric Mechanism of Action at the D2 Dopamine Receptor
R. Benjamin Free, Caroline A. Cuoco, Bing Xie, Yoon Namkung, Varun V. Prabhu, Blair K. A. Willette, Marilyn M. Day, Marta Sánchez‐Soto, J. Robert Lane, Stéphane A. Laporte, Lei Shi, Joshua E. Allen, David R. Sibley
Topics & Concepts
Dopamine receptor D2Allosteric regulationDopaminePharmacologyChemistryAntagonistDopamine receptorReceptorBiochemistryBiologyNeuroscienceReceptor Mechanisms and SignalingPharmacological Receptor Mechanisms and EffectsNeuropeptides and Animal Physiology