Impact of <i>FKS1</i> Genotype on Echinocandin <i>In Vitro</i> Susceptibility in Candida auris and <i>In Vivo</i> Response in a Murine Model of Infection
Dipti Sharma, Raees A. Paul, Shivaprakash M. Rudramurthy, Nisha Kashyap, Sanjay Bhattacharya, Rajeev Soman, Shamanth A. Shankarnarayan, Dipali Chavan, Shreya Singh, Parijit Das, Harsimran Kaur, Anup K. Ghosh, Rajendra Prasad, Kaustuv Sanyal, Arunaloke Chakrabarti
Abstract
Echinocandins are frontline antifungal agents in the management of invasive infections due to multidrug resistant Candida auris . The study aimed to evaluate echinocandin resistance in C. auris isolates of multicentric origin, identify the resistance mechanism, and analyze the pharmacodynamic response to caspofungin in a neutropenic mouse model of infection.
Topics & Concepts
EchinocandinEchinocandinsCandida aurisCaspofunginMicrobiologyBiologyGenotypeDrug resistanceMultiple drug resistanceVirologyMutantFungi imperfectiPharmacodynamicsTrimethoprimItraconazoleMycosisChitinAnidulafunginSerial passageAntifungal resistance and susceptibilityCancer therapeutics and mechanismsSignaling Pathways in Disease