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Recent development of urinary biomarkers for bladder cancer diagnosis and monitoring

Yuchen Zeng, Anqi Wang, Wei Lv, Qingqing Wang, Shiqi Jiang, Xiaoguang Pan, Fei Wang, Huanming Yang, Lars Bolund, Chunhua Lin, Peng Han, Yonglun Luo

2023Clinical and Translational Discovery17 citationsDOIOpen Access PDF

Abstract

Abstract Urine‐based liquid biopsy has emerged as a non‐invasive and effective tool for early screening and diagnosis of bladder cancer. This review provides a comprehensive overview of the current urine‐based biomarkers and methods for the detection and monitoring of bladder cancer. We focus on biomarkers including tumour DNAs, proteins, microbiome, tumour RNAs, long non‐coding RNAs, transfer RNA‐derived fragments, messenger RNAs, microRNAs, circular RNAs, exosomes and extrachromosomal circular DNA.

Topics & Concepts

Bladder cancerMedicineUrinary systemUrologyUrinary Bladder CancerCancerOncologyInternal medicineCancer-related molecular mechanisms researchMicroRNA in disease regulationRNA modifications and cancer
Recent development of urinary biomarkers for bladder cancer diagnosis and monitoring | Litcius