2,3,5,4′-Tetrahydroxy stilbene-2-Ο-β-D-glucoside, a mechanism-based inactivator of CYP2C19 and CYP3A4, potentiates hepatic protein adduction and hepatotoxicity induced by emodin in vivo
Xu Wang, Lingwen Dong, Guode Zhao, Weiwei Li, Ying Peng, Jiang Zheng
Topics & Concepts
CYP3A4PharmacologyHydroxylationCytochrome P450MetaboliteIn vivoMicrosomeChemistryEmodinIncubationPharmacokineticsBiochemistryLiver injuryEnzymeMedicineBiologyBiotechnologyPhytochemistry and biological activity of medicinal plantsPharmacological Effects of Natural CompoundsDrug-Induced Hepatotoxicity and Protection