Prolonged prothrombin time at admission predicts poor clinical outcome in COVID-19 patients
Lang Wang, Wenbo He, Xiaomei Yu, Dalong Hu, Hong Jiang
Abstract
BACKGROUND: The prognostic value of coagulation disorder in coronavirus disease 2019 (COVID-19) patients should be demonstrated. AIM: To investigate the abnormalities of coagulation parameters in the patients with COVID-19 and their prognostic values. METHODS: Consecutive patients admitted in the isolation ward of Renmin Hospital of Wuhan University from January 31 to February 5, 2020 with confirmed COVID-19 were included. The primary outcomes were death and survival as of March 11. Demographics, vital signs, comorbidities and laboratory tests were collected and compared between those who died and survivors. Logistic regression analysis for prognostic factors was performed. Kaplan-Meier analysis was used to compare the estimated survival rate between patients with prolonged prothrombin time and normal prothrombin time. RESULTS: < 0.001). CONCLUSION: Prothrombin time, concentration of fibrin degradation products, respiration rate and age were predictive factors for clinical outcomes of COVID-19 patients.