<i>N</i>-Thiohydroxy Succinimide Esters (NTSEs): Versatile Reagents for Selective Acyl and Acylthio Transfer
Yunfeng Li, Ya-Feng Wei, Jun Tian, Juan Zhang, Honghong Chang, Wen‐Chao Gao
Abstract
Differentiation between similarly reactive sites in molecules represents an ongoing challenge of organic synthesis. Herein we described one kind of versatile reagents, N-thiohydroxy succinimide esters (NTSEs), serving as both acyl and acylthio surrogates for the diverse synthesis of ketones, thioesters, amides, and acyl disulfides by selective cleavage of similarly reactive C–S and N–S bonds.
Topics & Concepts
SuccinimideChemistryReagentAcylationCombinatorial chemistryCleavage (geology)SuccinimidesOrganic chemistryStereochemistryCatalysisEngineeringGeotechnical engineeringFracture (geology)Sulfur-Based Synthesis TechniquesChemical Synthesis and AnalysisChemical Synthesis and Reactions