Novel quinoxaline derivatives as dual EGFR and COX-2 inhibitors: synthesis, molecular docking and biological evaluation as potential anticancer and anti-inflammatory agents
Eman A. Ahmed, Mamdouh F. A. Mohamed, Omran A. Omran
Abstract
Novel quinoxaline derivatives (2a–d, 3, 4a, 4b, 5–15) have been synthesized and screened for their in vitro anticancer and COX-2 inhibitory activities. Compounds 4a, 5, 11 and 13 proved to be the most potent anticancer and COX-2 inhibitors.
Topics & Concepts
ChemistryQuinoxalineIC50Docking (animal)MTT assayStereochemistryCarbohydrazidePotencyCytotoxicityIn vitroCombinatorial chemistryMedicinal chemistryBiochemistryOrganic chemistryNursingMedicineSynthesis and Biological EvaluationSynthesis and biological activityQuinazolinone synthesis and applications