Dearomatization of aryl sulfoxides: a switch between mono- and dual-difluoroalkylation
Xin Huang, Yage Zhang, Weijian Liang, Qifeng Zhang, Yaling Zhan, Lichun Kong, Bo Peng
Abstract
O enhances the electrophilicity of dearomatized intermediates, thus allowing for the adoption of a second DFESE to produce dual-difluoroalkylated alicycles.
Topics & Concepts
ArylSilylationDual (grammatical number)EtherChemistrySilyl etherCombinatorial chemistryProtocol (science)Organic chemistryMedicineCatalysisAlkylPhilosophyPathologyLinguisticsAlternative medicineSulfur-Based Synthesis TechniquesFluorine in Organic ChemistryCatalytic C–H Functionalization Methods