Histone lactylation-driven B7-H3 expression promotes tumor immune evasion
Zhibo Ma, Jianming Yang, Wenlong Jia, Le Li, Yixin Li, Junjie Hu, Wei Luo, Ronghui Li, Dawei Ye, Peixiang Lan
Abstract
This study uncovers a novel mechanism by which lactate modulates the immune microenvironment through the glycolysis pathway and B7-H3 expression, providing new avenues for lactate metabolism-targeted tumor immunotherapy.
Topics & Concepts
Histone H3Immune systemEvasion (ethics)HistoneCancer researchCell biologyChemistryBiologyImmunologyGeneGeneticsCancer Immunotherapy and BiomarkersImmune cells in cancerPeptidase Inhibition and Analysis