Prevalence of Atrial Fibrillation and Thromboembolic Risk in Wild-Type Transthyretin Amyloid Cardiomyopathy
Syed Bukhari, Amr F. Barakat, Yvonne S. Eisele, Ricardo Nieves, Sandeep Jain, Samir Saba, William P. Follansbee, Amy Brownell, Prem Soman
Abstract
ild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM) results from the age-related myocardial deposition of transthyretin amyloid fibrils, leading to a toxic-restrictive cardiomyopathy and progressive heart failure. 1 Amyloid infiltration of the atria and myocardium is thought to predispose patients to atrial fibrillation (AF) and a high thromboembolic risk. 2 In this study, we sought to determine the prevalence of AF in patients with ATTRwt-CM and the incidence and predictors of systemic thromboembolism in patients with ATTRwt-CM and AF.
Topics & Concepts
MedicineTransthyretinAtrial fibrillationCardiologyInternal medicineCardiomyopathyAmyloid (mycology)AmyloidosisHeart failurePathologyAmyloidosis: Diagnosis, Treatment, OutcomesParathyroid Disorders and TreatmentsEosinophilic Disorders and Syndromes