Transition metal complexes of cyclam with two 2,2,2-trifluoroethylphosphinate pendant arms as probes for <sup>19</sup>F magnetic resonance imaging
Filip Koucký, Jan Kotek, Ivana Cı́sařová, Jana Havlíčková, Vojtěch Kubíček, Petr Hermann
Abstract
Complexes of the title ligand with selected paramagnetic first-row transition metal ions exhibit short longitudinal relaxation times ( T 1 ) of 19 F nuclei and high stabilities, promising for potential use as effective 19 F MRI contrast agents.
Topics & Concepts
CyclamLigand (biochemistry)Relaxation (psychology)ChemistryTransition metalParamagnetismIonCrystallographyMagnetic resonance imagingMetalMetal ions in aqueous solutionNuclear magnetic resonanceMRI contrast agentResonance (particle physics)GadoliniumAtomic physicsPhysicsCondensed matter physicsOrganic chemistryBiochemistryPsychologyRadiologyCatalysisSocial psychologyMedicineReceptorLanthanide and Transition Metal ComplexesMagnetism in coordination complexesRadiopharmaceutical Chemistry and Applications