The prognostic role of NK cells and their ligands in squamous cell carcinoma of the head and neck: a systematic review and meta-analysis
Sangeeta K. Bisheshar, Emma J. de Ruiter, Lot A. Devriese, Stefan M. Willems
Abstract
: A favorable prognostic role of NK cells in HNSCC was found in this review. Some studies implied the opposite, indicating the fine balance between pro- and anti-tumor functions of NK cells. Future studies using homogeneous patient cohorts regarding tumor subsite and treatment modality, are necessary to further provide insight into the prognostic role of NK cells.
Topics & Concepts
Head and neck squamous-cell carcinomaGranzyme BMedicineCancer researchOncologyTumor-infiltrating lymphocytesInternal medicineCancerImmunotherapyHead and neck cancerImmunologyT cellImmune systemImmune Cell Function and InteractionCancer Immunotherapy and BiomarkersRNA Interference and Gene Delivery