Hepatocellular carcinoma in the non-cirrhotic liver
Yi Dong, Wen-Ping Wang, Won Jae Lee, Maria Franca Meloni, Dirk-Andre Clevert, Maria Cristina Chammas, Andrea Tannapfel, Antonella Forgione, Fabio Piscaglia, Christoph Frank Dietrich
Abstract
Liver cirrhosis is an established high-risk factor for HCC and the majority of patients diagnosed with HCC have cirrhosis. However, HCC also arises in non-cirrhotic livers in approximately 20 %of all cases. HCC in non-cirrhotic patients is often clinically silent and surveillance is usually not recommended. HCC is often diagnosed at an advanced stage in these patients. Current information about HCC in patients with non-cirrhotic liver is limited. Here we review the current knowledge on epidemiology, clinical features and imaging features of those patiens.
Topics & Concepts
MedicineHepatocellular carcinomaCirrhosisStage (stratigraphy)Internal medicineGastroenterologyRisk factorPathologyCarcinomaComplicationOncologyLiver cancerCancerNeoplasm stagingEpitheliomaTumor stageMEDLINEHepatocellular Carcinoma Treatment and PrognosisLiver Disease Diagnosis and TreatmentLiver Disease and Transplantation