Small CD4 mimetics sensitize HIV-1-infected macrophages to antibody-dependent cellular cytotoxicity
Annemarie Laumaea, Lorie Marchitto, Shilei Ding, Guillaume Beaudoin-Bussières, Jérémie Prévost, Romain Gasser, Debashree Chatterjee, Gabrielle Gendron‐Lepage, Halima Medjahed, Hung-Ching Chen, Amos B. Smith, Haitao Ding, John C. Kappes, Beatrice H. Hahn, Frank Kirchhoff, Jonathan Richard, Ralf Duerr, Andrés Finzi
Abstract
T cells. However, treatment of infected macrophages with small CD4 mimetics exposes vulnerable CD4-induced Env epitopes and sensitizes them to ADCC.
Topics & Concepts
Antibody-dependent cell-mediated cytotoxicityEpitopeCytotoxicityAntibodyChemistryVirologyDownregulation and upregulationIn vitroCell biologyBiologyMolecular biologyImmunologyGeneBiochemistryHIV Research and TreatmentImmune Cell Function and InteractionHIV/AIDS Research and Interventions