Rationally designed Ru(<scp>ii</scp>) metallacycles with tunable imidazole ligands for synergistical chemo-phototherapy of cancer
Le Tu, Chonglu Li, Chang Liu, Suya Bai, Jingfang Yang, Xian Zhang, Liying Xu, Xiaoxing Xiong, Yao Sun
Abstract
Herein, we construct a series of Ru(II) metallacycles with multimodal chemo-phototherapeutic properties, which exhibited much higher anticancer activity and better cancer-cell selectivity than cisplatin. The antitumor mechanism could be ascribed to the activation of caspase 3/7 and the resulting apoptosis. These results open new possibilities for Ru(II) metallacycles in biomedicine.
Topics & Concepts
ImidazoleChemistryCombinatorial chemistryMedicinal chemistryCancer researchStereochemistryMedicineSupramolecular Chemistry and ComplexesMetal complexes synthesis and propertiesPorphyrin and Phthalocyanine Chemistry