Antimicrobial Activity of Aztreonam-Avibactam and Comparator Agents When Tested against a Large Collection of Contemporary Stenotrophomonas maltophilia Isolates from Medical Centers Worldwide
Hélio S. Sader, Leonard R Duncan, S J Ryan Arends, Cecília G Carvalhaes, Mariana Castanheira
Abstract
Aztreonam-avibactam was tested against 1,839 Stenotrophomonas maltophilia isolates collected worldwide and demonstrated potent activity against isolates from all geographic regions and infection types (overall MIC 50/90 , 4/4 mg/liter; 97.8% inhibited at ≤8 mg/liter). Trimethoprim-sulfamethoxazole (TMP-SMX) (MIC 50/90 , ≤0.5/1 mg/liter; 95.4% susceptible) and minocycline (MIC 50/90 , 0.5/2 mg/liter; 99.
Topics & Concepts
Stenotrophomonas maltophiliaAztreonamAntimicrobialCeftazidime/avibactamStenotrophomonasMicrobiologyGram-negative bacterial infectionsAntibacterial agentBiologyMedicineAntibioticsPseudomonas aeruginosaBacteriaAntibiotic resistancePseudomonasCeftazidimeImipenemGeneticsInfections and bacterial resistance