Modeling pancreatic pathophysiology using genome editing of adult stem cell-derived and induced pluripotent stem cell (iPSC)-derived organoids
Sabrina T. Hirshorn, Nina G. Steele, Yana Zavros
2021American Journal of Physiology-Gastrointestinal and Liver Physiology10 citationsDOIOpen Access PDF
Abstract
The goal of this review is not only to provide highlights on the development of organoid technology but also to subsequently use this information to study the pathophysiology of those specific mutations in the formation of malignant pancreatic and gastric cancer.
Topics & Concepts
OrganoidCRISPRInduced pluripotent stem cellStem cellBiologyGenome editingPancreatic cancerComputational biologyCancer researchCancerBioinformaticsCell biologyEmbryonic stem cellGeneticsGenePluripotent Stem Cells ResearchCRISPR and Genetic EngineeringRenal and related cancers