Sex differences in right ventricular adaptation to pressure overload in a rat model
Tik-Chee Cheng, Diana M. Tabima, Laura R. Caggiano, Andrea L. Frump, Timothy A. Hacker, Jens C. Eickhoff, Tim Lahm, Naomi C. Chesler
Abstract
Sex differences in right ventricular mechanical efficiency and energetic adaptation to increased right ventricular afterload were measured. Despite sex-dependent differences in contractile and fibrotic responses, right ventricular mechanoenergetic adaptation was comparable between the sexes, suggesting a homeostatic target.
Topics & Concepts
Pressure overloadAdaptation (eye)Internal medicineCardiologyMedicinePsychologyMuscle hypertrophyNeuroscienceCardiac hypertrophyCardiovascular and exercise physiologyCardiovascular Function and Risk FactorsPulmonary Hypertension Research and Treatments