Design, synthesis and anti-tumor evaluation of plinabulin derivatives as potential agents targeting β-tubulin
Shiyuan Fang, Shijie Bi, Yannan Li, Shuai Tian, Huixin Xu, Lei Fu, Shixiao Wang, Yu Tang, Peiju Qiu
Topics & Concepts
ChemistryTubulinApoptosisCell cycleCell cycle checkpointMicrotubuleCell cultureStereochemistryCell growthIndole testLead compoundCancer researchToxicityIn vitroCombinatorial chemistryBiochemistryCell biologyOrganic chemistryBiologyGeneticsSynthesis and biological activityCancer therapeutics and mechanismsMicrotubule and mitosis dynamics