Micro-RNA Analysis in Pulmonary Arterial Hypertension
Cátia Ferreira, Mónica Abreu, Carla Marques, Lino Gonçalves, Rui Baptista, Henrique M. Girão
Abstract
Pulmonary arterial hypertension (PAH) is a rare, chronic disease of the pulmonary vasculature that is associated with poor outcomes. Its pathogenesis is multifactorial and includes micro-RNA (miRNA) deregulation. The understanding of the role of miRNAs in PAH is expanding quickly, and it is increasingly difficult to identify which miRNAs have the highest translational potential. This review summarizes the current knowledge of miRNA expression in PAH, discusses the challenges in miRNA analysis and interpretation, and highlights 4 promising miRNAs in this field (miR-29, miR-124, miR-140, and miR-204).
Topics & Concepts
microRNAPulmonary hypertensionPathogenesisMedicineDiseaseTranslational researchRNABioinformaticsComputational biologyCardiologyInternal medicineBiologyPathologyGeneGeneticsPulmonary Hypertension Research and TreatmentsMicroRNA in disease regulationCancer-related molecular mechanisms research