A Bacteroides fragilis protease activates host PAR2 to induce intestinal pain and inflammation
Markus Lakemeyer, Rocco Latorre, Kristýna Blažková, Hannah M. Wood, Dane D. Jensen, Nayab Shakil, Scott C. Thomas, Deepak Saxena, Yatendra Mulpuri, David Poolman, Paz Duran, Laura J. Keller, David E. Reed, Brian L. Schmidt, Nestor N. Jiménez-Vargas, Fangxi Xu, Alan Lomax, Nigel W. Bunnett, Matthew Bogyo
Topics & Concepts
ProteasesBiologyBacteroides fragilisInflammationMicrobiologyProteaseDownregulation and upregulationIrritable bowel syndromeProteolysisSecretionSerine proteaseMicrobiomeImmunologyBacteroidesIntestinal mucosaReceptorRegulatorCathepsinMetalloproteinaseCell biologyCysteine proteaseSignal transductionAminopeptidaseColitisCleavage (geology)BacteriaPathogenDysbiosisCatabolismInflammatory bowel diseaseFurinGastrointestinal tractSerineBacterial Identification and Susceptibility TestingClostridium difficile and Clostridium perfringens researchPharmacological Effects of Natural Compounds