A <i>p</i>-Coumaroyl-CoA Biosensor for Dynamic Regulation of Naringenin Biosynthesis in <i>Saccharomyces cerevisiae</i>
Dany Liu, Maria Sole Sica, Jiwei Mao, Lucy Fang-I Chao, Verena Siewers
Abstract
-coumaroyl-CoA synthesis within the naringenin production pathway. Using this approach, we obtained a naringenin titer of 47.3 mg/L upon external precursor feeding, representing a 15-fold increase over the nonregulated system.
Topics & Concepts
NaringeninSaccharomyces cerevisiaeBiosensorMetabolic engineeringBiochemistryMetaboliteBiosynthesisChemistryBiologyYeastEnzymeFlavonoidAntioxidantPlant biochemistry and biosynthesisPlant Gene Expression AnalysisPhotosynthetic Processes and Mechanisms