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Discovery of novel sulfonamide-containing aminophosphonate derivatives as selective COX-2 inhibitors and anti-tumor candidates

Bo Zhang, Xiuting Hu, Jin Gu, Yu‐Shun Yang, Yongtao Duan, Hai‐Liang Zhu

2020Bioorganic Chemistry32 citationsDOI

Topics & Concepts

HeLaChemistryApoptosisIC50EnzymeCell cycleDocking (animal)Cancer cellCell cycle checkpointSulfonamideCancerBiochemistryCancer researchIn vitroPharmacologyStereochemistryBiologyGeneticsMedicineNursingInflammatory mediators and NSAID effectsBone health and treatmentsSynthesis and biological activity
Discovery of novel sulfonamide-containing aminophosphonate derivatives as selective COX-2 inhibitors and anti-tumor candidates | Litcius