NELL2-cdc42 signaling regulates BAF complexes and Ewing sarcoma cell growth
Panneerselvam Jayabal, Fuchun Zhou, Xiufen Lei, Xiuye Ma, Barron Blackman, Susan T. Weintraub, Peter J. Houghton, Yuzuru Shiio
Abstract
populations in Ewing sarcoma, which display phenotypes consistent with high and low NELL2 signaling, respectively. We show that NELL2, CD133, and EWS-FLI1 positively regulate each other and upregulate BAF complexes and cell proliferation in Ewing sarcoma. These results reveal a signaling pathway regulating critical chromatin remodeling complexes and cancer cell proliferation.
Topics & Concepts
Cell biologyAutocrine signallingCDC42Signal transductionRHOAChromatinCell growthBiologyCancer researchChemistryReceptorGeneticsDNAAxon Guidance and Neuronal SignalingHippo pathway signaling and YAP/TAZSignaling Pathways in Disease