Quercetin Synergistically Enhances the Anticancer Efficacy of Docetaxel through Induction of Apoptosis and Modulation of PI3K/AKT, MAPK/ERK, and JAK/STAT3 Signaling Pathways in MDA-MB-231 Breast Cancer Cell Line.
Amir Safi, Esfandiar Heidarian, Reza Ahmadi
Abstract
and a significant increase in BAX level, as well as decrease in the levels of BCL2, pERK1/2, AKT, and STAT3 proteins (P < 0.05). The concomitant use of docetaxel and quercetin leads to the cell growth inhibition associated with the induction of apoptosis and inhibition of cell survival. Therefore, this study provides a promising therapeutic approach to enhance the efficacy of docetaxel in a less-toxic manner.
Topics & Concepts
DocetaxelViability assayProtein kinase BApoptosisPI3K/AKT/mTOR pathwayPharmacologyMAPK/ERK pathwayMTT assayQuercetinCancer researchCancer cellMedicineChemistryCancerSignal transductionInternal medicineBiochemistryAntioxidantCancer-related Molecular PathwaysCancer Mechanisms and TherapyPI3K/AKT/mTOR signaling in cancer