Development and pilot scale implementation of safe aerobic Cu/TEMPO oxidation in a batch reactor
Sylvain Lemaitre, Anne-Lise Romain, François Barière, Anthony Craquelin, Chloé Copin, Alexandre Jean
Abstract
A second generation process for the oxidation of benzylic alcohol 2, involved in the manufacture of Servier clinical candidate S44819 , is described. This protocol was safely implemented at a kilogram scale and displays better sustainability compared to the original method.
Topics & Concepts
Scale (ratio)Oxidation processProcess engineeringAlcoholProcess (computing)Computer scienceProtocol (science)SCALE-UPEnvironmental scienceChemistryChemical engineeringOperating systemOrganic chemistryEngineeringMedicinePhysicsAlternative medicineClassical mechanicsQuantum mechanicsPathologyOxidative Organic Chemistry ReactionsCatalysis and Oxidation ReactionsVanadium and Halogenation Chemistry