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Arabidopsis Coexpression Tool: a tool for gene coexpression analysis in Arabidopsis thaliana

Vasileios L. Zogopoulos, Georgia Saxami, Apostolos Malatras, Antonia Angelopoulou, Chih‐Hung Jen, William Duddy, Γεράσιμος Δάρας, Polydefkis Hatzopoulos, David R. Westhead, Ioannis Michalopoulos

2021iScience23 citationsDOIOpen Access PDF

Abstract

genes. ACT was developed to present subclades of coexpressed genes, as well as to perform gene set enrichment analysis, being unique in revealing enriched transcription factors targeting coexpressed genes. ACT offers a simple and user-friendly interface producing working hypotheses which can be experimentally verified for the discovery of gene partnership, pathway membership, and transcriptional regulation. ACT analyses have been successful in identifying not only genes with coordinated ubiquitous expressions but also genes with tissue-specific expressions.

Topics & Concepts

Arabidopsis thalianaArabidopsisTranscriptomeBiologyComputational biologyGeneMicroarray analysis techniquesDNA microarrayGene expressionGeneticsMicroarrayMutantGene expression and cancer classificationPlant Molecular Biology ResearchBioinformatics and Genomic Networks