Novel triphenylphosphonium amphiphilic conjugates of glycerolipid type: synthesis, cytotoxic and antibacterial activity, and targeted cancer cell delivery
Olga V. Tsepaeva, A. V. Nemtarev, Tatiana N. Pashirova, Michail V. Khokhlachev, Anna P. Lyubina, Syumbelya K. Amerkhanova, Alexandra D. Voloshina, В. Ф. Миронов
Abstract
of 10 is 0.3 μM toward HuTu-80. This is at the level of the reference drug doxorubicin. TPP-pharmacosomes (10/PC) increased the cytotoxic effect approximately 3 times toward HuTu-80 cells, providing high selectivity (SI = 480) compared to the normal liver cell line Chang liver.
Topics & Concepts
BetulinConjugateCytotoxicityChemistryPharmacophoreStereochemistryAmphiphileCombinatorial chemistryBiochemistryIn vitroOrganic chemistryMathematicsCopolymerMathematical analysisPolymerNatural product bioactivities and synthesisPlant biochemistry and biosynthesisBiological Activity of Diterpenoids and Biflavonoids