Painful diabetic neuropathy: The role of ion channels
Qi Wang, Yifei Ye, Linghui Yang, Lifan Xiao, Jin Liu, Wensheng Zhang, Guizhi Du
Abstract
Painful diabetic neuropathy (PDN) is a common chronic complication of diabetes that causes neuropathic pain and negatively affects the quality of life. The management of PDN is far from satisfactory. At present, interventions are primarily focused on symptomatic treatment. Ion channel disorders are a major cause of PDN, and a complete understanding of their roles and mechanisms may provide better options for the clinical treatment of PDN. Therefore, this review summarizes the important role of ion channels in PDN and the current drug development targeting these ion channels.
Topics & Concepts
MedicineDiabetic neuropathyIon channelDiabetes mellitusNeuropathic painPeripheral neuropathyComplicationIntensive care medicinePharmacologyInternal medicineEndocrinologyReceptorPain Mechanisms and TreatmentsIon Channels and ReceptorsIon channel regulation and function