Biologic Pathways Underlying Prognostic Radiomics Phenotypes from Paired MRI and RNA Sequencing in Glioblastoma
Qiuchang Sun, Yinsheng Chen, Chaofeng Liang, Yuanshen Zhao, Xiaofei Lv, Yan Zou, Kai Yan, Hairong Zheng, Dong Liang, Zhicheng Li
Abstract
= .048). The radiomics-associated pathways and key genes can be replicated in an external test set. Conclusion Individual radiomics phenotypes on MRI scans predictive of overall survival were driven by distinct key pathways involved in immune regulation, tumor proliferation, treatment responses, and cellular functions in glioblastoma, which could be reproduced externally. © RSNA, 2021
Topics & Concepts
RadiogenomicsRadiomicsMedicineHazard ratioPhenotypeOncologyProportional hazards modelBioinformaticsInternal medicineGeneRadiologyBiologyConfidence intervalGeneticsRadiomics and Machine Learning in Medical ImagingGlioma Diagnosis and TreatmentFerroptosis and cancer prognosis