Efficient one-pot synthesis of functionalised imidazo[1,2-<i>a</i>]pyridines and unexpected synthesis of novel tetracyclic derivatives by nucleophilic aromatic substitution
Charles R. K. Changunda, Bhumireddy Chinnachennaiahgari Venkatesh, William K. Mokone, Amanda L. Rousseau, Dean Brady, Manuel A. Fernandes, Moira L. Bode
Abstract
An efficient one-pot procedure for isocyanide preparation and imidazo[1,2-<italic>a</italic>]pyridine synthesis gave products able to undergo intramolecular ring-closure to afford novel tetracycles.
Topics & Concepts
ChemistryNucleophilic aromatic substitutionNucleophilic substitutionSubstitution (logic)Combinatorial chemistrySubstitution reactionNucleophileMedicinal chemistryStereochemistryOrganic chemistryCatalysisComputer scienceProgramming languageSynthesis and Reactivity of HeterocyclesSynthesis and Characterization of Heterocyclic CompoundsSynthesis of heterocyclic compounds