STK11/LKB1-Deficient Phenotype Rather Than Mutation Diminishes Immunotherapy Efficacy and Represents STING/Type I Interferon/CD8+ T-Cell Dysfunction in NSCLC
Anlin Li, Yuanyuan Wang, Zhixin Yu, Zihui Tan, Lina He, Sha Fu, Mengting Shi, Wei Du, Linfeng Luo, Zhichao Li, Jiaqing Liu, Yixin Zhou, Wenfeng Fang, Yunpeng Yang, Li Zhang, Shaodong Hong
Topics & Concepts
MedicineStingPhenotypeImmunotherapyInterferonCD8STK11MutationCancer researchCytotoxic T cellStimulator of interferon genesImmunologyInternal medicineGeneGeneticsCancerImmune systemIn vitroBiologyKRASColorectal cancerAerospace engineeringInnate immune systemEngineeringCancer Immunotherapy and Biomarkersinterferon and immune responsesLung Cancer Treatments and Mutations