NAADP: From Discovery to Mechanism
Timothy F. Walseth, Andreas H. Guse
Abstract
Nicotinic acid adenine dinucleotide 2’-phosphate (NAADP) is a naturally occurring nucleotide that has been shown to be involved in the release of Ca 2+ from intracellular stores in a wide variety of cell types, tissues and organisms. Current evidence suggests that NAADP may function as a trigger to initiate a Ca 2+ signal that is then amplified by other Ca 2+ release mechanisms. A fundamental question that remains unanswered is the identity of the NAADP receptor. Our recent studies have identified HN1L/JPT2 as a high affinity NAADP binding protein that is essential for the modulation of Ca 2+ channels.
Topics & Concepts
Mechanism (biology)Computational biologyNeuroscienceChemistryData scienceCognitive scienceComputer scienceBiologyPsychologyEpistemologyPhilosophyCalcium signaling and nucleotide metabolismAdvancements in PLL and VCO TechnologiesRadio Frequency Integrated Circuit Design