Rapid construction of γ-lactam containing 3,3-disubstituted oxindoles <i>via</i> a silver-catalyzed cascade radical bicyclization reaction
Lin Xie, Ruizhe Cao, Yingxue Huang, Qian Zhang, Zeguo Fang, Dong Li
Abstract
An efficient cascade bicyclization strategy for the construction of γ-lactam containing 3,3-disubstituted oxindole derivatives is described, which enables the sequential assembly of both unactivated and activated double bonds in one pot.
Topics & Concepts
OxindoleChemistryCascadeCombinatorial chemistryLactamCatalysisCascade reactionReaction conditionsStereochemistryOrganic chemistryChromatographyCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsRadical Photochemical Reactions