PPARα mediates night neon light-induced weight gain: role of lipid homeostasis
Yishuang Luo, Julin Yang, Jinyu Kang, Kuihao Chen, Xiaofeng Jin, Frank J. Gonzalez, Aiming Liu
Abstract
PPARα mediated weight gain of HFD-treated mice exposed to night neon light. More lipids were synthesized in the liver and transported to peripheral tissue leading to adaptive metabolism and lipid deposition in the adipose tissue. These data revealed an important mechanism of obesity induced by artificial light pollution where PPARα was implicated.
Topics & Concepts
EndocrinologyInternal medicineAdipose tissueLipid metabolismCircadian rhythmAdipocyteChemistryBiologyLipid dropletMedicineAdipose Tissue and MetabolismCircadian rhythm and melatoninBirth, Development, and Health