NOD2 Deficiency Promotes Intestinal CD4+ T Lymphocyte Imbalance, Metainflammation, and Aggravates Type 2 Diabetes in Murine Model
Daniela Carlos, Malena M. Pérez, Jefferson Antônio Leite, Fernanda A. Rocha, Larissa M. S. Martins, Camila A. Pereira, Thais Fernanda de Campos Fraga‐Silva, Taís A. Pucci, Simone G. Ramos, Niels Olsen Saraiva Câmara, Vânia Luiza Deperon Bonato, Rita C. Tostes, João S. Silva
Abstract
genera in these mice compared to HFD-fed WT mice. These alterations were associated with disrupted tight-junctions expression, augmented serum LPS, and bacterial translocation into VAT. Overall, NOD2 activation is required for a protective Th17 over Th1 immunity in the gut, which seems to decrease gram-negative bacteria outgrowth in gut microbiota, attenuating the endotoxemia, metainflammation, and protecting against obesity-induced T2D.
Topics & Concepts
Insulin resistanceDysbiosisType 2 diabetesEndocrinologyBiologyInternal medicineImmunologyGut floraTLR4InflammationDiabetes mellitusMedicineGut microbiota and healthAdipokines, Inflammation, and Metabolic DiseasesTryptophan and brain disorders