Role of the Mycobacterium tuberculosis ESX-4 Secretion System in Heme Iron Utilization and Pore Formation by PPE Proteins
November Sankey, Haley Merrick, Padam Singh, Janet Rogers, Amit R. Reddi, Steven D. Hartson, Avishek Mitra
Abstract
M. tuberculosis ( Mtb ) is completely dependent on iron acquisition in the host to cause disease. The largest source of iron for Mtb in the human host is heme.
Topics & Concepts
Mycobacterium tuberculosisTuberculosisSecretionHemeMicrobiologyHost (biology)DiseaseChemistryImmunologyBiologyMedicineBiochemistryInternal medicinePathologyGeneticsEnzymeIron Metabolism and DisordersBacteriophages and microbial interactionsBacterial Genetics and Biotechnology