A modular mRNA platform for programmable induction of tumour-specific immunogenic cell death
Songtao Dong, Shannon J. Tsai, Yue Xu, Fanglin Gong, Tiana L. Young, Nicholas C. Solek, D Chen, Lauren Healy, Margarita Savguira, Muye Zhou, Jingan Chen, Alex Golubovic, Rick Xing Ze Lu, Tingzhen He, B Wu, Benjamin H. Lok, Housheng Hansen He, Bowen Li
Topics & Concepts
Messenger RNAImmunogenic cell deathImmune systemCancer researchImmunotherapyUntranslated regionNanomedicineCellTumor microenvironmentCancer immunotherapyMelanomaMicrovesiclesBiologymicroRNAImmune checkpointMedicineCell biologyImmunologySystemic administrationExosomeDendritic cellDelivery systemChemistryModular designThree prime untranslated regionTranscriptomeRNARNA Interference and Gene DeliveryNanoplatforms for cancer theranosticsCancer Research and Treatments