DFT insight into mechanism of the Ni(II)-catalyzed enantioselective Michael addition: A combined computational and experimental study
Vadim A. Shiryaev, Dmitry S. Nikerov, A. N. Reznikov, Yu. N. Klimochkin
Topics & Concepts
Michael reactionChemistryEnantioselective synthesisAldehydeNucleophileDiethyl malonateIntramolecular forceProtonationMedicinal chemistryHydrogen bondNucleophilic additionAdductDimethyl malonateNitronateCatalysisReagentStereochemistryOrganic chemistryMoleculeNitroAlkylIonChemical Reaction MechanismsAsymmetric Hydrogenation and CatalysisAsymmetric Synthesis and Catalysis