Anti-skin aging effects and bioavailability of collagen tripeptide and elastin peptide formulations in young and middle-aged women
Shan Lü, Silu Zhang, Yun Wang, Jiayi Ni, Tiantian Zhao, Guoxun Xiao
Abstract
Collagen peptides (CP), including tripeptides and elastin peptides (EP), are known for their in vitro and in vivo anti-skin aging effects. Despite positive results in animal models, the combination effects of CP and EP and the bioavailability of CP in human studies, particularly in young and middle-aged women, remain underexplored. To evaluate the effects of an orally administered collagen drink combining CP and EP on the skin health of young and middle-aged women. A single-center, randomized, double-blind, parallel-controlled trial was conducted, utilizing the WONDERLAB® fish collagen tripeptide beverage. Participants consumed the drink over an 8-week period. Compared to the placebo group, the collagen drink group showed significant improvements in skin hydration (39.19% increase), transepidermal water loss (33.45% decrease), skin elasticity (25.37% increase), dermal collagen content (21.64% increase), pore size (7.94% decrease), wrinkle length (18.09% decrease), skin smoothness (2.85% improvement), and skin roughness (15.32% decrease). Overall pore volume decreased by 60%, and visual assessments indicated a decrease in skin luminosity by 15.20% and smoothness index by 22.55%. Mass spectrometry demonstrated a significant increase in collagen efficacy components, including blood pH and GPH levels (P<0.05). The study confirmed the combination nourishing and anti-skin aging effects of EP and CP on the skin of young and middle-aged women, demonstrating significant improvements in various skin parameters and good bioavailability of collagen peptides.