Transcriptional pathways linked to fetal and maternal hepatic dysfunction caused by gestational exposure to perfluorooctanoic acid (PFOA) or hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) in CD-1 mice
Bevin E. Blake, Colette N. Miller, Helen Nguyen, Vesna A. Chappell, Trina P. Phan, Dhiral Phadke, Michele R. Balik-Meisner, Deepak Mav, Ruchir Shah, Suzanne E. Fenton
Abstract
>0.92). These findings show shared biological pathways of liver toxicity for PFOA and GenX in maternal and fetal livers in CD-1 mice. The limited overlap in specific DEGs between the dam and fetus suggests the developing liver responds differently than the adult liver to these chemical stressors. This work helps define mechanisms of hepatic toxicity of two structurally unique PFAS and may help predict latent consequences of developmental exposure.
Topics & Concepts
Perfluorooctanoic acidFetusTranscriptomeOffspringChemistryPregnancyTransplacentalAndrologyInternal medicineEndocrinologyBiologyMedicineBiochemistryGenePlacentaGene expressionGeneticsPer- and polyfluoroalkyl substances researchToxic Organic Pollutants ImpactBirth, Development, and Health