Extracellular matrix degrading enzyme with stroma-targeting peptides enhance the penetration of liposomes into tumors
Mayumi Ikeda, Yongsheng Gao, Suyog Shaha, Liwen Wang, Kyung Soo Park, Mayuka Nakajima, Omokolade Adebowale, Samir Mitragotri
Topics & Concepts
HyaluronidaseChemistryHyaluronic acidDoxorubicinExtracellular matrixDrug deliveryCollagenaseConjugateCancer researchBiochemistryPharmacologyEnzymeMedicineChemotherapyInternal medicineMathematical analysisMathematicsOrganic chemistryAnatomyNanoparticle-Based Drug DeliveryPineapple and bromelain studiesPeptidase Inhibition and Analysis