Irradiation combined with PD-L1−/− and autophagy inhibition enhances the antitumor effect of lung cancer via cGAS-STING-mediated T cell activation
Xinrui Zhao, Songling Hu, Liang Zeng, Xinglong Liu, Yimeng Song, Yuhong Zhang, Qianping Chen, Yang Bai, Jianghong Zhang, Haowen Zhang, Yan Pan, Chunlin Shao
Abstract
T cells that in turn act on the tumor cells with amplified immune responses in PD-L1-deficient host, indicating a potential sandwich therapy strategy of RT combined with PD-L1 blockage and autophagy inhibition.
Topics & Concepts
AutophagyBystander effectCancer researchCD8Abscopal effectImmune systemChemistryCytotoxic T cellStingImmunotherapyBiologyCell biologyApoptosisImmunologyBiochemistryIn vitroAerospace engineeringEngineeringCancer Immunotherapy and Biomarkersinterferon and immune responsesImmunotherapy and Immune Responses